微生物學,博士,講師,碩士生導師。
電子信箱:[email protected]

【個人簡介】
2014年長沙理工大學獲工學學士學位,2021年湖南師范大學獲理學博士學位。2022年4月至今,長沙理工大學食品與生物工程學院講師、碩士生導師,“功能微生物創(chuàng)制及精準發(fā)酵研究團隊”核心成員之一。研究方向為食品微生物代謝工程與合成生物學,主要從事食品功能微生物的挖掘、機制解析、代謝調控、定向改造等食品微生物技術研究。在Journal of Agricultural and Food Chemistry、Microbial Cell Factories、ACS synthetic biology等SCI期刊發(fā)表論文16篇。主持湖南省自然科學基金青年項目1項,湖南省教育廳優(yōu)秀青年項目1項,長沙市自然科學基金青年項目1項,參與完成科技部“973計劃”專項項目及國家自然科學基金面上項目各1項。
【主講課程】
1.《微生物學》、《微生物學實驗》、《生物工程綜合實驗》(本科生);
2.《高級微生物學》、《現(xiàn)代食品微生物學》、《基因工程》(碩士生);
3.《酶工程研究進展》(博士生)。
【主要研究領域】
1.傳統(tǒng)發(fā)酵食品功能微生物資源挖掘;
2.微生物代謝工程及其調控;
3.微生物基因編輯及合成生物學。
【主要科研項目】
1.湖南省自然科學青年基金項目:食竇魏斯氏菌降解釀造醬油中有害生物胺的機制研究(2024JJ6022),5萬元,2024-2026年,主持;
2.湖南省教育廳優(yōu)秀青年基金項目:降生物胺魏斯氏菌的篩選及其關鍵基因的解析(23B0306),6萬元,2023-2025年,主持。
【主要科研論文】
[1]Jianli Tang, Haocheng He, Yunlong Li, Zhudong Liu, Ziyuan Xia, Li Cao, Zirong Zhu, Ling Shuai, Yang Liu, Qianqian Wan, Yuewen Luo, Youming Zhang, Jie Rang* and Liqiu Xia*. Comparative proteomics reveals the effect of transcriptional regulator Sp13016 on butenyl-spinosyn biosynthesis in Saccharopolyspora pogona [J]. Journal of Agricultural and Food Chemistry, 2021, 69(42): 12554-12565.
[2]Jianli Tang, Jianming Chen, Yang Liu, Jinjuan Hu, Ziyuan Xia, Xiaomin Li, Haocheng He, Jie Rang, Yunjun Sun, Ziquan Yu, Jun Cui and Liqiu Xia*. The global regulator PhoU positively controls growth and butenyl-spinosyn biosynthesis in Saccharopolyspora pogona [J]. Frontiers in Microbiology, 2022, 13: 904627.
[3]Jianli Tang, Zirong Zhu, Haocheng He, Zhudong Liu, Ziyuan Xia, Jianming Chen, Jinjuan Hu, Li Cao, Jie Rang*, Ling Shuai, Yang Liu, Yunjun Sun, Xuezhi Ding, Shengbiao Hu, Liqiu Xia*. Bacterioferritin: a key iron storage modulator that affects strain growth and butenyl-spinosyn biosynthesis in Saccharopolyspora pogona [J]. Microbial Cell Factories, 2021, 20(1): 157.
[4]Haocheng He, Jianli Tang, Jianming Chen, Jinjuan Hu, Zirong Zhu, Yang Liu, Ling Shuai, Li Cao, Zhudong Liu, Ziyuan Xia, Xuezhi Ding, Shengbiao Hu, Youming Zhang, Jie Rang*, Liqiu Xia*. Flaviolin-like gene cluster deletion optimized the butenyl-spinosyn biosynthesis route in Saccharopolyspora pogona [J]. ACS synthetic biology, 2021, 10(10):2740-2752.
[5]Fan Huang, Jianli Tang, Lian He, Xuezhi Ding, Shaoya Huang, Youming Zhang, Yunjun Sun and Liqiu Xia*. Heterologous expression and antitumor activity analysis of syringolin from Pseudomonas syringae pv. syringae B728a [J]. Microbial Cell Factories, 2018, 17(1): 31.
[6]Zhudong Liu, Zirong Zhu, Jianli Tang, Haocheng He, Qianqian Wan, Yuewen Luo, Weitao Huang, Ziquan Yu, Yibo Hu, Xuezhi Ding and Liqiu Xia*. RNA-seq-based transcriptomic analysis of Saccharopolyspora spinosa revealed the critical function of PEP phosphonomutase in replenishment pathway [J]. Journal of Agricultural and Food Chemistry, 2020, 68(49):14660-14669.
[7]Zhudong Liu, Jie Xiao, Jianli Tang, Yang Liu, Ling Shuai, Li Cao, Ziyuan Xia, Xuezhi Ding, Jie Rang*, Liqiu Xia*. Effects of acuC on the growth development and spinosad biosynthesis of Saccharopolyspora spinosa [J]. Microbial Cell Factories, 2021, 20(1): 141.
[8]Lian He, Huijun Yang, Jianli Tang, Zhudong Liu, Yiyan Chen, Binghua Lu, Haocheng He, Sijia Tang, Yunjun Sun, Fei Liu, Xuezhi Ding, Youming Zhang, Shengbiao Hu* and Liqiu Xia*. Intestinal probiotics E. coli Nissle 1917 as a targeted vehicle for delivery of p53 and Tum-5 to solid tumors for cancer therapy [J]. Journal of Biological Engineering, 2019, 13: 58.