微生物學，博士（后），中共黨員，副教授，碩士研究生導師，入選湖南省湖湘青年英才，擔任湖南省食品科學技術學會理事，湖南省生物化學與分子生物學會青年委員會委員。
電話：0731-85258365
電子信箱：[email protected]
【個人簡介】
2019年畢業于廣西大學獲微生物學博士學位，2019-2021年于江南大學食品科學與資源挖掘全國重點實驗室從事博士后研究。2021年12月入職長沙理工大學食品與生物工程學院，現為生物工程系副教授、碩士研究生導師。研究方向為代謝工程與合成生物學、蛋白質工程、食品生物技術。先后主持國家自然科學基金、湖湘青年英才（荷尖）人才計劃、湖南省自然科學基金、湖南省教育廳、全國重點實驗室開放課題等科研項目和研究生教研教改項目。在國內外學術期刊發表科研論文50余篇，教研教改論文2篇，參與編寫英文專著2章節，指導學生獲全國大學生生命科學競賽科學探究類第八屆（一等獎1項）、第九屆（一等獎和三等獎各1項）；生命科學競賽創新創業類第八屆（三等獎1項）、第九屆（二等獎1項）；國家級大學生創新創業訓練計劃項目指導教師；本科生優秀畢業論文指導教師；獲湖南省研究生課程思政教學課堂競賽三等獎、長沙理工大學首屆研究生課程思政教學課堂競賽一等獎。兼任Frontiers in Bioengineering and Biotechnology、Metabolites客座編輯，Food and Health、Food Innovation and Advances、Journal of Future Foods、Advanced Biotechnology青年編委；國家自然科學基金函評專家、教育部學位論文評審專家、生命科學競賽網評專家、湖南科技廳和廣西科技廳專家等。
【主講課程】
1.《現代分子生物學（雙語）》、《食品生物技術進展》、《酶工程研究進展》（博士生）；
2.《合成生物學》、《制藥工藝與技術》、《高級生物化學》（碩士生）；
3.《生化分離》（碩士留學生）；
4.《生物化學A》、《生物化學A（實驗）》（本科生）。
【主要研究領域】
1.新型食品酶資源挖掘與催化機理、酶分子設計與改造；
2.生物活性肽功能挖掘及作用機制研究。
【主要科研項目】
1.國家自然科學基金青年項目：計算設計提高D-來蘇糖異構酶熱穩定性的分子改造及其機理研究（32201963），2023-2025年，主持；
2.湖南省自然科學基金青年項目：基于酸堿氨基酸置換的D-來蘇糖異構酶嗜酸性改造及其分子機制研究（2023JJ40018），2023-2025，主持；
3.湖南省創新平臺與人才計劃：湖湘青年英才科技創新類（2023RC3137），2023-2026，主持。
【主要科研論文】
[1]Hao Wu, Qiuming Chen, Wenli Zhang*, Wanmeng Mu. Overview of strategies for developing high thermostability industrial enzymes: Discovery, mechanism, modification and challenges [J]. Critical Reviews in Food Science and Nutrition, 2023, 63(14):2057-2073.
[2]Hao Wu, Ming Yi, Xiaoyi Wu, Yating Ding, Minghui Pu, Li Wen, Yunhui Cheng, Wenli Zhang, Wanmeng Mu. Engineering the thermostability of D-lyxose isomerase from Caldanaerobius polysaccharolyticus via multiple computer-aided rational design for efficient synthesis of D-mannose [J]. Synthetic and Systems Biotechnology, 2023,8:323-330.
[3]Hao Wu, Cuie Guang, Wenli Zhang*, Wanmeng Mu. Recent development of phenyllactic acid: Physicochemical properties, biotechnological production strategies and applications [J]. Critical Reviews in Biotechnology, 2023, 43(2):293-308.
[4]Hao Wu, Wanmeng Mu*. Application prospects and opportunities of inorganic nanomaterials for enzyme immobilization in the food-processing industry [J]. Current Opinion in Food Science, 2022, 47:100909.
[5]Hao Wu, Ming Chen, Cuie Guang, Wenli Zhang*, Wanmeng Mu. Identification of a novel recombinant D-lyxose isomerase from Thermoprotei archaeon with high thermostable, weak-acid and nickel ion dependent properties [J]. International Journal of Biological Macromolecules, 2020,164:1267-1274.
[6]Hao Wu, Wei Zeng, Lei Chen, Bo Yu, Ye Guo, Guiguang Chen, Zhiqun Liang*. Integrated multi-spectroscopic and molecular docking techniques to probe the interaction mechanism between maltase and 1-deoxynojirimycin, an α-glucosidase inhibitor [J]. International Journal of Biological Macromolecules, 2018,114:1194-1202.
[7]Hao Wu, Ye Guo, Lei Chen, Guiguang Chen, Zhiqun Liang*. A novel strategy to regulate 1-deoxynojirimycin production based on its biosynthetic pathway in Streptomyces lavendulae [J]. Frontiers in Microbiology, 2019,10:1968.
[8]Hao Wu, Ming Chen, Cuie Guang*, Wenli Zhang, Wanmeng Mu. Characterization of a recombinant D-mannose-producing D-lyxose isomerase from Caldanaerobius polysaccharolyticus [J]. Enzyme and Microbial Technology, 2020,138:109553.
[9]Hao Wu, Jiawei Huang, Yu Deng*, Wenli Zhang*, Wanmeng Mu. Production of L-ribose from L-arabinose by co-expression of L-arabinose isomerase and D-lyxose isomerase in Escherichia coli [J]. Enzyme and Microbial Technology, 2020,132:109443.
[10]Hao Wu+, Wei Zeng+, Guiguang Chen+, Ye Guo, Chengzhen Yao, Juan Li, Zhiqun Liang*. Spectroscopic techniques investigation on the interaction of glucoamylase with 1-deoxynojirimycin: Mechanistic and conformational study [J]. Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy, 2019,206:613-621.
[11]Hao Wu, Wenli Zhang, Wanmeng Mu*. Recent studies on the biological production of D-mannose [J]. Applied Microbiology and Biotechnology, 2019,103:8753-8761.
[12]Hao Wu+, Xianbo Cheng+, Yongfeng Zhu, Wei Zeng, Guiguang Chen, Zhiqun Liang*. Purification and characterization of a cellulase-free, thermostable endo-xylanase from Streptomyces griseorubens LH-3 and its use in biobleaching on eucalyptus kraft pulp [J]. Journal of Bioscience and Bioengineering, 2018,125(1):46-51.
[13]Hao Wu+, Guiguang Chen+, Yaxi Bian, Wei Zeng, Bihong Sun, Zhiqun Liang*. Identification and characterization of a new agar-degrading strain with the novel properties of saccharides inhibition and nitrogen fixation [J]. Journal of Microbiology, 2017,55(6):475-482.
[14]Hao Wu*, Qiuming Chen. D-Mannose-producing isomerases and epimerases: properties, comparisons, and different strategies. In Book Novel enzymes for functional carbohydrates production, 1st ed; Editor Wanmeng Mu, Wenli Zhang, Qiuming Chen, Eds; Publisher: Springer Nature Singapore, 2021, 43-61.
[15]Hao Wu*, Wei Xu. L-Arabinose isomerase: sources, biochemical properties, and its use to produce D-tagatose. In Book Novel enzymes for functional carbohydrates production, 1st ed; Editor Wanmeng Mu, Wenli Zhang, Qiuming Chen, Eds; Publisher: Springer Nature Singapore, 2021, 63-84.
[16]Hao Wu, Ye Guo, Lei Chen, Guiguang Chen, Zhiqun Liang*. A novel strategy to regulate 1-deoxynojirimycin production based on its biosynthetic pathway in Streptomyces lavendulae [J]. Front Microbiol, 2019,10:1968.
[17]Hao Wu+, Guiguang Chen+, Yaxi Bian, Wei Zeng, Bihong Sun, Zhiqun Liang*. Identification and characterization of a new agar-degrading strain with the novel properties of saccharides inhibition and nitrogen fixation [J]. J Microbiol, 2017,55(6):475-482
[18]吳昊,黃嘉葦,張文立,沐萬孟*.重組共表達大腸桿菌細胞從D-葡萄糖一鍋法生產D-甘露糖[J].微生物學通報,2020,47(7):2151-2160.
[19]Fan Zhu, Shuwen He, Ce Ni, Ying Wu, Hao Wu*, Li Wen*. Study on the structure–activity relationship of rice immunopeptides based on molecular docking [J]. Food Chemistry X:2024, 21, 101158.
[20]Yun-Hui Cheng, Bu-Qing Liu, Bo Cui, Li Wen, Zhou Xu, Mao-Long Chen, Hao Wu*.Alanine substitution to determine the effect of LR5 and YR6 rice peptide structure on antioxidant and anti-inflammatory activity [J]. Nutrients, 2023, 15(10):2373.
[21]Geng Chen, Hao Wu*, Yingying Zhu, Li Wan, Wenli Zhang, and Wanmeng Mu*. Glycosyltransferase from Bacteroides gallinaceum is a novel α-1,3-fucosyltransferase that can be used for 3-fucosyllactose production in vivo by metabolically engineered Escherichia coli [J]. Journal of Agricultural and Food Chemistry, 2022,70(6):1934-1942.
[22]Duoduo Hu, Hao Wu*, Yingying Zhu, Wenli Zhang, Wanmeng Mu*. Engineering Escherichia coli for highly efficient production of lacto-N-triose II from N-acetylglucosamine, the monomer of chitin [J]. Biotechnology for Biofules, 2021,14:198
[23]Ming Chen, Wenli Zhang, Hao Wu*, Cuie Guang, Wanmeng Mu. Mannitol: physiological functionalities, determination methods, biotechnological production, and applications [J]. Applied Microbiology and Biotechnology, 2020,104:6941-6951.
[24]Ming Chen, Hao Wu*, Wenli Zhang, Wanmeng Mu. Microbial and enzymatic strategies for the production of L-ribose [J]. Applied Microbiology and Biotechnology, 2020,104:3321-3329.
[25]Wenli Zhang, Wanmeng Mu, Hao Wu*, Zhiqun Liang*. An overview of the biological production of 1-deoxynojirimycin: current status and future perspective [J]. Applied Microbiology and Biotechnology, 2019,103:9335-9344.
[26]吳曉怡, 吳昊*, 楊燦, 文詩雨, 段艷婷, 譚文芝, 謝雨菲, 程云輝, 文李*. 蛋白質工程提升糖酶熱穩定性研究進展[J].食品科學,2024,45 (19): 263-271.
[27]韓鵬薇, 易彤, 李虹輝, 吳昊*, 李彥, 褚武英. 蝦殼源蛋白水解物降糖降脂活性評價及肽序分析[J].食品與機械 ,2024,40(4): 148-157.
每一位研究生都有無窮的潛力，歡迎有志于從事食品生物技術研究的同學報考！這里將給予大家最好的平臺，共同創造美好未來！
